Which of the following factors will not cause change in gene frequency ?

Options

A. Mutation
B. gene flow
C. Large population
D. Genetic recombination

Answer

To determine which factor will not cause a change in gene frequency, we need to analyze each option provided in the question.

### Step-by-Step Solution:

1. **Understanding Gene Frequency**:
- Gene frequency refers to the proportion of a specific allele (variant of a gene) within a population. It can change due to various factors such as mutation, gene flow, genetic drift, and recombination.

2. **Analyzing the Options**:
- **Option 1: Mutation**:
- Mutation is a change in the DNA sequence. It introduces new alleles into a population and can significantly alter gene frequency. Thus, mutation does cause a change in gene frequency.

- **Option 2: Gene Flow**:
- Gene flow refers to the transfer of alleles from one population to another through migration. This process can introduce new genetic material into a population, thereby changing gene frequency. Therefore, gene flow does cause a change in gene frequency.

- **Option 3: Large Population**:
- A large population size itself does not inherently change gene frequency. While it may affect genetic drift (the random fluctuations in allele frequencies), simply increasing the population size does not directly alter the frequency of alleles. Thus, a large population does not cause a change in gene frequency.

- **Option 4: Genetic Recombination**:
- Genetic recombination occurs during meiosis when chromosomes exchange genetic material. This process can create new combinations of alleles, leading to changes in gene frequency. Therefore, genetic recombination does cause a change in gene frequency.

3. **Conclusion**:
- Among the options analyzed, the factor that does not cause a change in gene frequency is **Option 3: Large Population**.

### Final Answer:
**Large Population** will not cause a change in gene frequency.