There is a tRNA with anticodon UAC. If we apply the wobble hypothesis , then this tRNA can decode which of these codons ?

Options

A. It can decode AUG, AUG, AUU, AUA
B. It can decode AUG and AUG but not AUU and AUA
C. It can decode AUG but not AUG, AUU and AUA
D. It cannot decode any one of these codons AUG,AUG,AUU and AUA

Answer

To solve the problem, we need to determine which codons can be decoded by a tRNA with the anticodon UAC, using the wobble hypothesis.

### Step-by-Step Solution:

1. **Identify the Anticodon**: The given tRNA has the anticodon UAC.

2. **Determine the Corresponding Codon**: The codon that pairs with the anticodon UAC is AUG. This is because in the process of translation, the anticodon pairs with the codon in a complementary manner (A pairs with U, and C pairs with G).

3. **Identify the Amino Acid**: The codon AUG codes for the amino acid Methionine, which is also the start codon for protein synthesis.

4. **Apply the Wobble Hypothesis**: The wobble hypothesis states that the third position of the codon can be flexible in pairing. This means that the tRNA with the anticodon UAC can also pair with codons that have variations in the third nucleotide.

5. **List Possible Codons**:
- The codon AUG can be paired with UAC (the original pairing).
- The codon AUC can also be paired with UAC due to the flexibility in the third position (U can pair with A or G).
- The codons AUU and AUA cannot be paired with UAC, as they do not match the first two positions.

6. **Conclusion**: The tRNA with the anticodon UAC can decode the codon AUG and possibly AUC, but not AUU or AUA.

### Final Answer:
The tRNA with the anticodon UAC can decode the codon AUG.