What would be the genotype of :
(i) An individual who is carrier of sickle cell anaemia gene but apparently unaffected .
(ii) An individual affected with the disease .

Options

A. (i) `Hb^AHb^S`
(ii) `Hb^A Hb^S`
B. (i) `Hb^AHb^S`
(ii) `Hb^S Hb^S`
C. (i) `Hb^SHb^S`
(ii) `Hb^A Hb^S`
D. (i) `Hb^AHb^A`
(ii) `Hb^A Hb^S`

Answer

To solve the question regarding the genotypes of individuals related to sickle cell anemia, we need to understand the genetics behind this condition.

### Step-by-Step Solution:

1. **Understanding Sickle Cell Anemia**:
- Sickle cell anemia is a genetic disorder caused by a mutation in the hemoglobin gene. It is inherited in an autosomal recessive manner.
- The two alleles involved are HbA (normal hemoglobin) and HbS (sickle cell hemoglobin).

2. **Genotypes**:
- There are three possible genotypes for individuals concerning sickle cell anemia:
- **HbAA**: Homozygous normal (not affected).
- **HbAS**: Heterozygous (carrier, but not affected).
- **HbSS**: Homozygous sickle cell (affected).

3. **(i) Carrier Individual**:
- An individual who is a carrier of the sickle cell anemia gene but is apparently unaffected would have the genotype **HbAS**. This means they have one normal allele (HbA) and one sickle cell allele (HbS). They do not exhibit symptoms of the disease but can pass the sickle cell allele to their offspring.

4. **(ii) Affected Individual**:
- An individual affected by sickle cell anemia would have the genotype **HbSS**. This means they have two copies of the sickle cell allele and will exhibit the symptoms of the disease.

### Final Answer:
- (i) The genotype of an individual who is a carrier of sickle cell anemia gene but apparently unaffected is **HbAS**.
- (ii) The genotype of an individual affected with the disease is **HbSS**.