Wobble hypothesis cannot be applied to the tRNA Carrying which of the following amino acids .

Options

A. Tryptophan and cysteine
B. Cysteine and serine
C. Tryptophan and Methionine
D. Serine and Methionine

Answer

To solve the question regarding the wobble hypothesis and which amino acid it cannot be applied to, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Wobble Hypothesis**: The wobble hypothesis suggests that the third position of a codon can vary and still code for the same amino acid. This means that multiple codons can correspond to a single amino acid.

2. **Identify the Options**: The question provides several options of amino acids. We need to determine which amino acid does not follow the wobble hypothesis.

3. **Analyze Each Option**:
- **Option A: Tryptophan and Cysteine**:
- Tryptophan is encoded by a single codon (UGG). Therefore, it does not have multiple codons that can code for it, which means wobble hypothesis does not apply.
- Cysteine has two codons (UGU and UGC), so it does follow the wobble hypothesis.
- **Option B: Cysteine and Serine**:
- As previously mentioned, cysteine has two codons.
- Serine has six codons (UCU, UCC, UCA, UCG, AGU, AGC), so it follows the wobble hypothesis.
- **Option C: Tryptophan and Methionine**:
- Tryptophan, as noted, has only one codon (UGG).
- Methionine is encoded by a single codon (AUG), which is also a start codon. Thus, it does not follow the wobble hypothesis.
- **Option D: Serine and Methionine**:
- Serine has multiple codons, so it follows the wobble hypothesis.
- Methionine, as stated, has only one codon, so it does not follow the wobble hypothesis.

4. **Conclusion**: The amino acid that cannot have the wobble hypothesis applied to it is Tryptophan, as it is encoded by a single codon (UGG).

### Final Answer:
The correct answer is **Tryptophan**.