All are correct with respect to the Human Genome project , except

Options

A. Its goal was to determine the sequence of the 3 billion chemical base pairs that make up human DNA
B. Caenorhabditis elegans and Arabidopsis are the non-human model organisms, that have been sequence
C. The sequence of chromosome -1 was completely only in May 2006 , this was the last of the 24 human chromosomes to be sequenced
D. 14 million locations are identified in humans with single base DNA differences

Answer

**Step-by-Step Solution:**

1. **Understanding the Human Genome Project (HGP):**
- The Human Genome Project was an international scientific research project aimed at mapping and understanding all the genes of the human species. The primary goal was to sequence the 3 billion base pairs in human DNA.

2. **Evaluating the Statements:**
- **Statement 1:** The goal of the HGP was to sequence the 3 billion base pairs in human DNA.
- This statement is **correct**.

- **Statement 2:** Non-human model organisms like *C. elegans* (a nematode) and *Arabidopsis* (a plant) have been sequenced.
- This statement is also **correct**. These organisms were used as models in genetic studies.

- **Statement 3:** The sequence of chromosome 1 was completed in May 2006 and was the last of the 23 chromosomes to be sequenced.
- This statement is **incorrect**. Chromosome 1 was actually one of the first chromosomes to be sequenced, not the last.

- **Statement 4:** 14 million locations with single base differences were identified in humans.
- This statement is **incorrect**. The correct number is 1.4 million locations of single nucleotide polymorphisms (SNPs), not 14 million.

3. **Identifying the Incorrect Statement:**
- From the evaluation, we find that Statement 3 and Statement 4 are incorrect. However, since the question asks for a single statement that is incorrect, we focus on the one that is more widely recognized as a misconception, which is Statement 4 regarding the number of SNPs.

4. **Conclusion:**
- The statement that is incorrect with respect to the Human Genome Project is that 14 million locations are identified with single base differences. The correct number is 1.4 million.

**Final Answer:**
- The statement that is incorrect regarding the Human Genome Project is: "14 million locations are identified in humans with single base differences."

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