Which of the following statements is the most appropriate for sickle cell anaemia

Options

A. It connot be treated with iron supplements
B. it is a molecular disease
C. It confers resistance to acquiring malaria
D. All of the above

Answer

D

Explanation

(Sickle-cell anaemia is an autosome linked recessive trait. In this genatic disorder point mutation in `beta`-globin chain results in change of glutamate (glutamic acid) to valine at sixth position . Olny the homozyhous individuals for `Hb_(2)^(s)`,i.e., `Hb^(s) Hb^(s)` show the diseased phenotype. The heterozygous `(Hb^(s)// Hb^(A))` are carriers.
It is also known that heterozygotes, having both types of heamoglobin, show resistance to malaria infection because the body targets the P. falsiparum (protozoan) infected cells for destruction of RBC.