Based on your understanding of genetic code, explain the formation of any abnormal heamoglobin molecule. What are the known consequences of such a change?

Explanation

Due to point mutation in `beta`-globin chain of haemoglobin molecule, glutamic acid (Glu) is replaced by valine (Val) at the sixth position.
Under stress condition erythrocytes lose their circular shape and become sickle -shaped . As a result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus affect blood supply to different organs.