Which of the following reaction does not produce amine ?

Options

A. Gabriel's synthesis
B. Hoffmann bromoamide reaction
C. Carbylamine reaction
D. Mendius reaction

Explanation

To determine which of the following reactions does not produce amines, we need to analyze each option provided in the question.

### Step-by-Step Solution:

1. **Identify the Reactions**:
We have four reactions to consider. The first two options are Gabriel synthesis and Hofmann bromamide reaction, both of which are known to produce amines. The third option is the carbylamine reaction, and the fourth option is the Mendeleev reaction.

2. **Gabriel Synthesis**:
Gabriel synthesis involves the reaction of phthalimide with an alkyl halide, followed by hydrolysis. This reaction produces primary amines. Therefore, this reaction does produce amines.

3. **Hofmann Bromamide Reaction**:
The Hofmann bromamide reaction involves the conversion of a primary amide to a primary amine with the loss of one carbon atom. This reaction also produces amines.

4. **Carbylamine Reaction**:
The carbylamine reaction involves the reaction of primary amines with chloroform (CHCl3) in the presence of a strong base (like potassium hydroxide). The product of this reaction is isocyanide (or carbylamine), not a primary amine. Hence, this reaction does not produce amines.

5. **Mendeleev Reaction**:
The Mendeleev reaction is another method for synthesizing amines, typically involving the reaction of alkyl halides with ammonia or amines. Thus, this reaction produces amines.

6. **Conclusion**:
After analyzing all the reactions, we find that the carbylamine reaction (option 3) is the only reaction that does not produce amines. Therefore, the answer is option C.

### Final Answer:
**Option C: Carbylamine Reaction does not produce amine.**

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