In which of these disease's does the patient doesn't have the same number of chromosomes as the rest ?

Options

A. Down's syndrome
B. Edward's syndrome
C. Turner's syndrome
D. Klinefelter's syndrome

Answer

To solve the question regarding which disease results in a patient having a different number of chromosomes compared to the normal count, we will analyze each of the listed syndromes:

1. **Down Syndrome**:
- Also known as Trisomy 21.
- In Down syndrome, there is an extra copy of chromosome 21.
- Normal human cells have 46 chromosomes, but individuals with Down syndrome have 47 chromosomes (46 + 1).

2. **Edwards Syndrome**:
- Also known as Trisomy 18.
- In Edwards syndrome, there is an extra copy of chromosome 18.
- Like Down syndrome, individuals with Edwards syndrome have 47 chromosomes (46 + 1).

3. **Turner Syndrome**:
- This syndrome occurs when there is a missing X chromosome.
- Individuals with Turner syndrome have only one X chromosome (XO), resulting in a total of 45 chromosomes (46 - 1).

4. **Klinefelter Syndrome**:
- This syndrome occurs when there is an extra X chromosome in males.
- Individuals with Klinefelter syndrome typically have an XXY genotype, resulting in a total of 47 chromosomes (46 + 1).

Now, summarizing the chromosome counts:
- Down Syndrome: 47 chromosomes
- Edwards Syndrome: 47 chromosomes
- Turner Syndrome: 45 chromosomes
- Klinefelter Syndrome: 47 chromosomes

**Conclusion**:
The disease where the patient does not have the same number of chromosomes as the rest (which is typically 46) is **Turner Syndrome**, as it results in a total of 45 chromosomes.