Select the WRONG statement with respect to glycolysis.

Options

A. It occurs outside mitochondria.
B. It is an anaerobic phase.
C. Glucose undergoes partial oxidation to form 2 molecules of pyruvic acid.
D. Glucose is phosphorylated to glucose-6-phosphate by isomerase enzyme.

Answer

To solve the question, "Select the WRONG statement with respect to glycolysis," we will analyze each option provided in the question step by step.

### Step-by-Step Solution:

1. **Understand Glycolysis**: Glycolysis is a metabolic pathway that converts glucose into pyruvate, producing a small amount of ATP and NADH in the process. It occurs in the cytoplasm of the cell and does not require oxygen.

2. **Evaluate Option 1**:
- Statement: "It occurs outside mitochondria."
- Analysis: This statement is **correct** because glycolysis occurs in the cytoplasm, which is outside the mitochondria.

3. **Evaluate Option 2**:
- Statement: "It is an anaerobic phase."
- Analysis: This statement is also **correct**. Glycolysis can occur in the absence of oxygen, making it an anaerobic process.

4. **Evaluate Option 3**:
- Statement: "Glucose undergoes partial oxidation to form two molecules of pyruvic acid."
- Analysis: This statement is **correct** as well. During glycolysis, one molecule of glucose is indeed converted into two molecules of pyruvate (or pyruvic acid).

5. **Evaluate Option 4**:
- Statement: "Glucose is phosphorylated to Glucose-6-phosphate by isomerase enzyme."
- Analysis: This statement is **incorrect**. The phosphorylation of glucose to glucose-6-phosphate is catalyzed by the enzyme **hexokinase**, not an isomerase.

6. **Conclusion**: The wrong statement regarding glycolysis is found in **Option 4**.

### Final Answer:
The wrong statement with respect to glycolysis is **Option 4**.

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