Which of the following will react with `CHCl_3+alc`. KOH ?

Options

A. Adenine and lysine
B. Thymine and proline
C. Adenine and thymine
D. Adenine and proline

Answer

To determine which of the given compounds will react with `CHCl3 + alc. KOH`, we need to understand the nature of the reaction involved. This reaction is known as the Carbylamine reaction, which specifically occurs with primary amines to form isocyanides.

### Step-by-Step Solution:

1. **Understanding the Carbylamine Reaction**:
- The Carbylamine reaction occurs when primary amines react with chloroform (CHCl3) in the presence of alcoholic KOH. This reaction will not occur with secondary or tertiary amines.

2. **Identifying Primary Amines**:
- We need to analyze the structures of the given compounds to identify which ones contain primary amines (RNH2).

3. **Analyzing Each Compound**:
- **Adenine**:
- Adenine has an amino group (NH2) attached to its structure. Since this is a primary amine, it will react positively in the Carbylamine reaction.
- **Lysine**:
- Lysine is an amino acid that has two amino groups (NH2) at different positions. The presence of a primary amine means it will also react positively in the Carbylamine reaction.
- **Thymine**:
- Thymine contains a nitrogen atom but it is part of a secondary amine structure (NH group). Therefore, it will not react positively in the Carbylamine reaction.
- **Proline**:
- Proline is a cyclic amino acid and contains a secondary amine. Thus, it will not react positively in the Carbylamine reaction.

4. **Conclusion**:
- The compounds that will react with `CHCl3 + alc. KOH` are adenine and lysine, as they both contain primary amines. Thymine and proline will not react because they contain secondary amines.

### Final Answer:
The compounds that will react with `CHCl3 + alc. KOH` are **Adenine and Lysine**.