Drugs can inhibit the catalytic activity of enzymes by binding at

Options

A. Active sites
B. Allosteric sites
C. Both 1 and 2
D. Core of enzyme

Answer

**Step-by-Step Solution:**

1. **Understanding Enzymes and Their Function:**
- Enzymes are biological catalysts that speed up chemical reactions in the body. They have specific regions called active sites where substrates bind to form products.

2. **Defining Inhibition:**
- Inhibition refers to the process where a substance (in this case, a drug) decreases or stops the catalytic activity of an enzyme. This can affect how efficiently enzymes perform their function.

3. **Identifying Binding Sites:**
- Enzymes have two main types of binding sites:
- **Active Site:** The region where the substrate binds and the reaction occurs.
- **Allosteric Site:** A different site on the enzyme where other molecules can bind, which can change the enzyme's shape and function.

4. **Mechanism of Inhibition:**
- When a drug binds to the allosteric site, it alters the shape of the enzyme. This change can prevent the substrate from binding to the active site, thereby inhibiting the enzyme's activity.

5. **Conclusion:**
- Therefore, drugs can inhibit the catalytic activity of enzymes by binding at the **allosteric site**.

**Final Answer:**
- Drugs can inhibit the catalytic activity of enzymes by binding at the **allosteric site**.

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