Identify the incorrect statement with reference of nucleolus

Options

A. The content of it is continuous with the rest of nucleoplasm
B. It is not a membrane bound structure
C. It is a site for active protein synthesis
D. Larger and more numerous nucleoli are present in cells actively carrying out protein synthesis.

Answer

To identify the incorrect statement regarding the nucleolus, we can analyze each of the provided statements step by step.

### Step-by-Step Solution:

1. **Statement Analysis**:
- **Statement 1**: "The content of it is continuous with the rest of nucleoplasm."
- **Analysis**: This statement is correct. The nucleolus is not membrane-bound and is indeed continuous with the nucleoplasm.

2. **Statement 2**: "It is not a membrane-bound structure."
- **Analysis**: This statement is also correct. The nucleolus lacks a surrounding membrane, which allows it to be part of the nucleoplasm.

3. **Statement 3**: "It is the site for the active protein synthesis."
- **Analysis**: This statement is incorrect. The nucleolus is primarily the site for ribosomal RNA (rRNA) synthesis and assembly of ribosomal subunits, not for active protein synthesis.

4. **Statement 4**: "Larger and more numerous nucleoli are present in cells that actively carry out protein synthesis."
- **Analysis**: This statement is correct. Cells that are actively synthesizing proteins often have larger and more numerous nucleoli because they require more ribosomes for translation.

### Conclusion:
Based on the analysis, the incorrect statement regarding the nucleolus is **Statement 3**: "It is the site for the active protein synthesis."