How has the sequencing of humen genome opened new windows for treatment of verious genetic disorders. Discuss amongst your classmates.

Given below is the representation of a relevant part of amino acid composition of the beta -chain of haemoglobin, related to the shape of human red blood cells. (a) Is this representation of the sequence of amino acids indicating a normal human or a sufferer from a certain blood related genetic disease ? Give reason in support of your answer. (b) Why is the disease referred to as a Mendelian disorder ? Explain.

In the following items, cach passage consists of six sentences. The first sentence (S_1) and the final scntence (S_6) are given in the beginning. The middle four sentences in each have been removed and jumbled up. These are labelled P, Q, R and S. You are required to find out the proper sequence of the four sentences and mark accordingly on the Answer Sheet. S_1 : A reporter is someone who gathers and writes news. S_6 : The reporter and the editor are both called newsmen. P: An editor is someone who prepares all the news for printing in the newspaper. Q: A reporter cannot do a good job unless he has a good understanding of the requirements of the editor of his newspaper R: The editor decides how important each news story is and where it should be placed S: Many editors are former reporters. The proper sequence should be

A square sheet of paper has been folded and punched as shown in the question figure. You have to figure out from amongst the four answer figures, how it will ap- pear when opened ?

Two children, A and B aged 4 and 5 years respectively visited a hospital with a similar genetic disorder. The girl A was provided enzyme-replacement therapy and was advised to revisit periodically for further treatment. The girl, B was, however, given a therapy that did not require revisit for further treatment. (a) Name the ailments the two girls were suffering from ? (b) Why did the treatment provided to girl A required repeated visits ? (c) How was the girl B cured permanently ?