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How is a mature, functional insulin horm...

How is a mature, functional insulin hormone different from its pro-hormone form?

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How is mature insulin different from proinsulin secreted humans pancreas in human? Explain how was human functional insulin produced using rDNA technology. Why is the functional insulim thus produced considered better than the ones used earlier by diabetic patients?

The pro-hormone insulin is processed to become a fully mature and functional insulin hormone by removal of