List one difference between prosthetic group and coenzyme.

Explanation

**Step-by-Step Text Solution:**

1. **Definition of Prosthetic Group:**
A prosthetic group is a non-polypeptide unit that is tightly and permanently attached to an enzyme. It is essential for the enzyme's activity and is often found at the active site of the enzyme.

2. **Definition of Coenzyme:**
A coenzyme is also a non-polypeptide molecule, but it is not permanently attached to the enzyme. Instead, it binds transiently during the enzymatic reaction and is released afterward.

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