Which of these statements is incorrect ?

Options

A. Glycolysis occurs in cytosol.
B. Glycolysis operates as long as it is supplied with NAD that can pick up hydrogen atoms.
C. Enzymes of TCA cycle are present in mitochonddrial matrix.
D. Oxidative phosphorylation takes place in outer mitochondrial membrane.

Answer

To determine which of the statements is incorrect, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Evaluate the First Statement: "Glycolysis occurs in cytosol."**
- Glycolysis is indeed a series of reactions that take place in the cytoplasm (or cytosol) of the cell. It involves the breakdown of glucose into pyruvate, producing ATP and NADH in the process.
- **Conclusion:** This statement is **correct**.

2. **Evaluate the Second Statement: "Glycolysis operates as long as it is supplied with NAD that picks up hydrogen atoms."**
- NAD (Nicotinamide adenine dinucleotide) is an essential coenzyme in glycolysis. It acts as an electron carrier, accepting hydrogen atoms during the oxidation of glucose.
- **Conclusion:** This statement is also **correct**.

3. **Evaluate the Third Statement: "Enzymes of TCA cycle are present in the mitochondrial matrix."**
- The Tricarboxylic Acid (TCA) cycle, also known as the Krebs cycle, occurs in the mitochondrial matrix. The enzymes involved in this cycle are indeed located in this part of the mitochondria.
- **Conclusion:** This statement is **correct**.

4. **Evaluate the Fourth Statement: "Oxidative Phosphorylation takes place in the outer mitochondrial membrane."**
- Oxidative phosphorylation occurs in the inner mitochondrial membrane, not the outer mitochondrial membrane. This process involves the electron transport chain and ATP synthesis.
- **Conclusion:** This statement is **incorrect**.

### Final Answer:
The incorrect statement is: **"Oxidative Phosphorylation takes place in the outer mitochondrial membrane."**

---