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Why is the introduction of genetically e...

Why is the introduction of genetically engineered lymphocytes into a ADA deficiency patient not a permanent cure ? Suggest a possible permanent cure.

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### Step-by-Step Solution: 1. **Understanding ADA Deficiency**: - ADA (Adenosine Deaminase) deficiency is a genetic disorder that affects the immune system. Individuals with this condition lack the enzyme ADA, which is crucial for the breakdown of toxic metabolites in lymphocytes. This leads to a compromised immune system. 2. **Introduction of Genetically Engineered Lymphocytes**: - In current treatments, lymphocytes (a type of white blood cell) from the patient are genetically engineered to express the ADA enzyme. These modified lymphocytes are then infused back into the patient. ...
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(i) What is gene therapy? Name the first clinical case where it was used. (ii) Why is the introduction of genetically engineered lymphocytes into ADA deficiency patient not a permanent cure? Suggest a possible permanent cure.

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Assertion: In gene therapy of SCID, a patient requires periodic infusion of genetically engineered lymphocytes Reason :If the ADA gene is introducted into cells at early embryonic stage, it could be a permanent cure

Write the function of adenosine deaminase enzyme. State the cause of ADA deficiency in humans. Mention a possible permanent cure for a ADA deficiency patient.

A patient is suffering from ADA deficiency. Can he b e cured? How?

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Introduction of ADA gene into bone marrow cells at embryonic stages may act as a permanent cure is which of the following disease ?

XII BOARD PREVIOUS YEAR PAPER ENGLISH-XII BOARDS-SECTION-B
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