Mention any two autosomal genetic disorder with their symptoms.

Explanation

Sickle cell anaemia and Down.s syndrome.
= (i) Sickle cell anaemia : The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension causing the change in the shape of the RBCs from biconcave disc elongated. Sickle like structure.
= (ii) Down.s syndrome : The affected individual is short statured with small round head, furrowed tongue and partially open mouth.
= Physical and mental development is retarded.