In an experiment, common Tobacco Mosaic Virus (TMV) and its mutant strain 'HR' were used to prepare hybrid particles with 'HR' nucleic acid and TMV protein coat. These hybrids were mixed with antibodies against 'HR' strains. If this mixture is applied to plant materials, it will result in , .

Options

A. loss of infectivity of virus particles due to inactivation of nucleic acids
B. loss of infectivity due to inactivation of protein coat.
C. intact infectivity because only neutrilised
D. unchanged infectivity because neither nucleic acid not protein coat is neutralised.

Explanation

To solve the question, we need to analyze the experiment involving the Tobacco Mosaic Virus (TMV) and its mutant strain 'HR.' Here’s a step-by-step breakdown of the reasoning:

### Step 1: Understand the Components
- The experiment involves two types of viruses: the common Tobacco Mosaic Virus (TMV) and its mutant strain 'HR.'
- Hybrid particles are created using 'HR' nucleic acid and TMV protein coat.

**Hint:** Identify the components involved in the experiment and their roles.

### Step 2: Analyze the Hybrid Particles
- The hybrid particles consist of the nucleic acid from the 'HR' strain and the protein coat from TMV.
- When these hybrid particles are introduced to a plant, they can potentially infect the plant.

**Hint:** Consider how hybrid viruses function in terms of infection and what components are necessary for infectivity.

### Step 3: Introduce the Antibodies
- The hybrid particles are mixed with antibodies specifically against the 'HR' strain.
- These antibodies will target and neutralize the 'HR' nucleic acid present in the hybrid particles.

**Hint:** Think about the role of antibodies in viral infections and how they interact with viral components.

### Step 4: Determine the Effect of Antibodies
- Since the antibodies neutralize the 'HR' nucleic acid, the infectivity of the hybrid particles is compromised.
- The neutralization leads to a loss of infectivity because the genetic material (nucleic acid) necessary for replication and infection is inactivated.

**Hint:** Reflect on what happens to a virus's ability to infect when its nucleic acid is neutralized.

### Step 5: Conclusion
- Therefore, the result of applying this mixture to plant materials will be a loss of infectivity of the virus particles due to the inactivation of the nucleic acids.

**Final Answer:** The correct answer is: "loss of infectivity of virus particles due to inactivation of nucleic acids."

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