Which phase of mitosis is essentially the reverse of prophase in terms of nuclear changes?

Options

A. S-phase
B. Anaphase
C. Telophase
D. Interphase

Explanation

To answer the question "Which phase of mitosis is essentially the reverse of prophase in terms of nuclear changes?", we need to analyze the processes that occur during prophase and then identify the phase that exhibits the opposite changes.

### Step-by-Step Solution:

1. **Understanding Prophase**:
- Prophase is the first stage of mitosis.
- During prophase, the nuclear membrane begins to disappear, and by late prophase, it is completely gone.
- Chromosomes condense and become visible, moving from the nucleus into the cytoplasm.

2. **Identifying Nuclear Changes**:
- Key changes during prophase include:
- Disappearance of the nuclear membrane.
- Condensation of chromatin into distinct chromosomes.

3. **Identifying the Opposite Phase**:
- The phase that is essentially the reverse of prophase will involve:
- Reappearance of the nuclear membrane.
- Decondensation of chromosomes back into chromatin.

4. **Recognizing Telophase**:
- Telophase is the final stage of mitosis.
- In telophase, the nuclear membrane reforms around the separated genetic material.
- Chromosomes decondense back into a less compact form, resembling a "ball of wool".

5. **Conclusion**:
- Since telophase involves the opposite changes of prophase (nuclear membrane reappearing and chromatin decondensing), it is the correct answer to the question.

### Final Answer:
The phase of mitosis that is essentially the reverse of prophase in terms of nuclear changes is **Telophase**.

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