What is the correct sequence in Ornithine Cycle of urea formation?
(i) Ornithine
(ii) Arginine
(iii) Arginosuccinic acid
(iv) Urea
(v) Citrulline
Select the correct answer using the codes given below

Options

A. (i), (ii), (iii), (v), (iv)
B. (i), (v), (iii), (ii), (iv)
C. (i), (v), (ii), (iii), (iv)
D. (i), (iii), (v), (ii), (iv)

Answer

To determine the correct sequence in the Ornithine Cycle of urea formation, we can follow these steps:

### Step-by-Step Solution:

1. **Start with Ornithine**: The cycle begins with the amino acid ornithine.
- **Hint**: Remember that ornithine is the starting point of the cycle.

2. **Formation of Citrulline**: Ornithine combines with carbamoyl phosphate to form citrulline.
- **Hint**: Think about how ornithine interacts with other molecules to progress in the cycle.

3. **Formation of Argininosuccinic Acid**: Citrulline then reacts with aspartate (an amino acid) to form argininosuccinic acid.
- **Hint**: Consider the role of aspartate in the cycle and how it contributes to the formation of argininosuccinic acid.

4. **Formation of Arginine**: Argininosuccinic acid is then cleaved to produce arginine and fumarate.
- **Hint**: Focus on the transformation that occurs here, where one compound breaks down into two.

5. **Release of Urea**: Finally, arginine is hydrolyzed to release urea and regenerate ornithine, completing the cycle.
- **Hint**: Remember that urea is a waste product that needs to be eliminated from the body.

### Correct Sequence:
Based on the steps outlined above, the correct sequence in the Ornithine Cycle is:
1. Ornithine (i)
2. Citrulline (v)
3. Argininosuccinic acid (iii)
4. Arginine (ii)
5. Urea (iv)

Thus, the correct order is: **(i) → (v) → (iii) → (ii) → (iv)**.

### Final Answer:
The correct option based on the given codes is: **1, 5, 3, 2, 4**.