One of the following methods of transporation does not involve a change in extrinsic and intrinsic proteins ?

Options

A. Active transport
B. Simple diffusion
C. Facilitated diffusion
D. Both (2) & (3)

Answer

### Step-by-Step Solution:

1. **Understanding Transportation in Cells**:
- Transportation refers to the movement of solutes or solvents into and out of the cell. This can involve various methods, which may or may not require proteins.

2. **Identifying Types of Transport**:
- The main types of transport mentioned are:
- **Active Transport**: Requires energy (ATP) and often involves intrinsic and extrinsic proteins.
- **Simple Diffusion**: Movement from higher to lower concentration without the need for proteins.
- **Facilitated Diffusion**: Involves carrier proteins to help transport substances across the membrane.

3. **Analyzing Extrinsic and Intrinsic Proteins**:
- Extrinsic (or peripheral) proteins and intrinsic (or integral) proteins are part of the plasma membrane and often act as carriers for molecules.
- When these proteins are involved in transport, their shape and position may change.

4. **Determining Which Method Does Not Involve Protein Change**:
- **Active Transport**: Involves energy and proteins, leading to changes in protein structure.
- **Simple Diffusion**: Does not require proteins, hence there is no change in protein structure.
- **Facilitated Diffusion**: Involves proteins, leading to changes in their structure.

5. **Conclusion**:
- The method of transportation that does not involve a change in extrinsic and intrinsic proteins is **Simple Diffusion**.

### Final Answer:
**Simple Diffusion**