Restriction enzymes that are used in the construction of recombinant DNA are endonucleases which cut the DNA at 'specific-recognition sequence'. What would be the disadvantage if they do not cut the DNA at specific-recognition sequence?

Explanation

**Step-by-Step Solution:**

1. **Understanding Restriction Enzymes**:
- Restriction enzymes, also known as endonucleases, are proteins that cut DNA at specific sequences known as restriction sites.

2. **Importance of Specific Recognition Sequences**:
- These specific recognition sequences are crucial because they allow researchers to target and isolate specific genes or DNA fragments for cloning or analysis.

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