What is the significance of the Lederberg's experiment?

Explanation

**Step-by-Step Solution:**

1. **Introduction to Lederberg's Experiment**: The experiment was conducted by Joshua Lederberg in 1952 and is known as the replica plating experiment. It aimed to study the nature of mutations in bacteria.

2. **Setup of the Experiment**: Lederberg started with a bacterial culture where colonies were grown on a nutrient medium. He then used a velvet cloth to imprint these colonies onto two different types of media: one containing normal nutrients and the other containing antibiotics.

3. **Observations**: After allowing the bacteria to grow, Lederberg observed that all colonies grew on the normal medium. However, on the antibiotic medium, only a few colonies survived, which he identified as antibiotic-resistant colonies.

...