Consider the following four statements (I-IV) regarding kidney transplant and select the two correct ones out of these.
I. Even if a kidney transplant is proper the recipient may need to take immuno-suppresants for a long time.
II. The cell-mediated immune response is responsible for the graft rejection.
III. The B-lymphocytes are responsible for rejection of the graft.
IV. The acceptance or rejection of a kidney transplant depends on specific interferons.
The two correct statements are

Options

A. II and III
B. III and IV
C. I and III
D. I and II

Explanation

To solve the question regarding the statements about kidney transplants, we will analyze each statement one by one to determine which are correct.

### Step-by-Step Solution:

1. **Statement I**: "Even if a kidney transplant is proper the recipient may need to take immuno-suppressants for a long time."
- **Analysis**: This statement is true. After a kidney transplant, recipients typically need to take immunosuppressants for an extended period to prevent their immune system from rejecting the transplanted kidney.

2. **Statement II**: "The cell-mediated immune response is responsible for the graft rejection."
- **Analysis**: This statement is also true. The cell-mediated immune response, primarily involving T lymphocytes, plays a crucial role in recognizing and rejecting foreign tissues, such as transplanted organs.

3. **Statement III**: "The B-lymphocytes are responsible for rejection of the graft."
- **Analysis**: This statement is false. B-lymphocytes are primarily involved in the humoral immune response, which produces antibodies. They are not directly responsible for graft rejection, which is mainly mediated by T lymphocytes.

4. **Statement IV**: "The acceptance or rejection of a kidney transplant depends on specific interferons."
- **Analysis**: This statement is also false. Interferons are part of the innate immune response and are not specifically responsible for the acceptance or rejection of transplanted organs. The acceptance or rejection is more related to the immune system's ability to recognize self versus non-self cells.

### Conclusion:
Based on the analysis, the two correct statements regarding kidney transplants are:
- **Statement I**: True
- **Statement II**: True

Thus, the correct answer is **I and II**.

### Final Answer:
The two correct statements are I and II.

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