After entering T-cell, HIV first forms

Options

A. mRNA
B. ssDNA
C. dsDNA
D. dsRNA

Answer

To answer the question "After entering T-cell, HIV first forms," we can break down the process that occurs when HIV infects a T-cell.

### Step-by-Step Solution:

1. **Attachment to T-cell**: The HIV virus first attaches itself to the T-helper cell (a type of T-cell). This is facilitated by the interaction between the viral envelope proteins and the CD4 receptors on the T-cell surface.

**Hint**: Remember that the initial step involves the virus recognizing and binding to the host cell.

2. **Fusion with the T-cell membrane**: After attachment, the virus fuses with the T-cell membrane, allowing the viral contents to enter the T-cell.

**Hint**: Fusion is a critical step that allows the virus to deliver its genetic material into the host cell.

3. **Release of viral RNA**: Once inside the T-cell, the HIV releases its RNA genome into the cytoplasm of the host cell.

**Hint**: The viral RNA is essential for the next steps in the viral life cycle.

4. **Reverse transcription**: The viral RNA is then reverse transcribed into single-stranded DNA (ssDNA) by the enzyme reverse transcriptase, which is carried within the virus.

**Hint**: This process converts the viral RNA into DNA, which is a key step for integration into the host genome.

5. **Formation of double-stranded DNA**: The single-stranded DNA is then converted into double-stranded DNA (dsDNA) by the same enzyme.

**Hint**: The formation of double-stranded DNA is crucial for the next step of integration into the host's DNA.

6. **Integration into the host genome**: The double-stranded DNA is integrated into the host cell's genome, allowing the virus to hijack the host's cellular machinery for replication.

**Hint**: Integration is what allows the virus to persist in the host cell and replicate when the cell divides.

### Final Answer:
After entering the T-cell, HIV first forms **single-stranded DNA (ssDNA)**.