Incorrect statement in relation to nucleolus is

Options

A. It is a spherical structure
B. It is separated from nucleoplasm by nuclear envelope
C. It is the site of rRNA synthesis
D. They are larger and more numerous in cells actively angaged in protein sythesis

Answer

To determine the incorrect statement in relation to the nucleolus, we will analyze each option provided in the question step by step.

### Step-by-Step Solution:

1. **Understand the Structure of the Nucleolus**:
- The nucleolus is a prominent structure found within the nucleus of eukaryotic cells. It is primarily composed of RNA and proteins.

2. **Evaluate Each Statement**:
- **Statement A**: "It is a spherical structure."
- This statement is **correct**. The nucleolus is generally spherical in shape and is located within the nucleus.

- **Statement B**: "It is separated from nucleoplasm by nuclear envelope."
- This statement is **incorrect**. The nucleolus is not surrounded by a membrane; it is not separated from the nucleoplasm by a nuclear envelope. The nuclear envelope surrounds the entire nucleus, not the nucleolus itself.

- **Statement C**: "It is the site of RNA synthesis."
- This statement is **correct**. The nucleolus is indeed involved in the synthesis of ribosomal RNA (rRNA), which is a crucial component of ribosomes.

- **Statement D**: "They are larger and more numerous in cells actively engaged in protein synthesis."
- This statement is **correct**. In cells that are actively synthesizing proteins, the nucleolus tends to be larger and more numerous, as it is responsible for producing ribosomes which are essential for protein synthesis.

3. **Identify the Incorrect Statement**:
- After evaluating all the statements, we find that **Statement B** is the only incorrect statement regarding the nucleolus.

### Final Answer:
The incorrect statement in relation to the nucleolus is: **"It is separated from nucleoplasm by nuclear envelope."**

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