The centromere spilts during

Options

A. Anaphase
B. Telophase
C. Interphase
D. Prophase

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks during which phase of cell division the centromere splits. The options given are anaphase, telophase, interphase, and prophase.

2. **Identifying the Role of the Centromere**: The centromere is the region of a chromosome where the two sister chromatids are joined together. It plays a crucial role during cell division.

3. **Phases of Cell Division**:
- **Prophase**: This is the first stage of mitosis where the chromatin condenses into visible chromosomes, and the spindle fibers begin to form. However, the centromere does not split during this phase.
- **Metaphase**: The chromosomes align at the cell's equatorial plane, but the centromere has not yet split.
- **Anaphase**: This is the phase where the centromere splits. The sister chromatids are pulled apart towards opposite poles of the cell due to the contraction of spindle fibers.
- **Telophase**: This phase occurs after anaphase, where the chromatids reach the poles and the cell begins to divide, but the centromere has already split by this point.
- **Interphase**: This is the phase where the cell prepares for division, and it is not a part of mitosis.

4. **Conclusion**: The centromere splits during the **anaphase** of cell division.

**Final Answer**: The centromere splits during **anaphase**.

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