Enzyme required to catalyse the last step of glycolysis is

Options

A. Pyruvate dehydrogenase
B. Pyruvate kinase
C. Enolase
D. Phosphopyruvate dihinase

Answer

**Step-by-Step Solution:**

1. **Understanding Glycolysis**: Glycolysis is the metabolic pathway that converts glucose into pyruvate, producing a small amount of ATP in the process. It occurs in the cytoplasm and consists of ten enzymatic steps.

2. **Identifying the Last Step**: The last step of glycolysis involves the conversion of phosphoenolpyruvate (PEP) into pyruvate. This is a crucial step as it is where the final product of glycolysis, pyruvate, is formed.

3. **Recognizing the Enzyme**: The enzyme responsible for catalyzing this last step is known as pyruvate kinase. This enzyme facilitates the transfer of a phosphate group from PEP to ADP, resulting in the formation of ATP and pyruvate.

4. **Evaluating the Options**:
- Option A: Pyruvate dehydrogenase - This enzyme is involved in the conversion of pyruvate to acetyl-CoA, not in glycolysis.
- Option B: Pyruvate kinase - This is the correct enzyme for the last step of glycolysis.
- Option C: Enolase - This enzyme is involved in an earlier step of glycolysis, converting 2-phosphoglycerate to phosphoenolpyruvate.
- Option D: Phosphopyruvate dehydrogenase - This option is incorrect as it does not exist in the context of glycolysis.

5. **Conclusion**: Based on the understanding of glycolysis and the role of the enzymes involved, the correct answer is option B: pyruvate kinase.

**Final Answer**: The enzyme required to catalyze the last step of glycolysis is pyruvate kinase (Option B).

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