Which statement is wrong for Krebs' cycle ?

Options

A. There are three points in the cycle where `NAD^(+)` is reduced to `NADH+ H^(+)`
B. There is one point in the cycle where `FAD^(+)` is rreduced to `FADH_(2)`
C. During conversion of succinyl CoA to succinic acid, a molecule of GTP is synthesised
D. The cycle starts with condensation of acetyl group (acetyl CoA) with pyruvic acid to yield citric acid

Answer

To determine which statement is wrong regarding the Krebs cycle, let's analyze the key components and steps of the cycle.

### Step-by-Step Solution:

1. **Understanding the Krebs Cycle**:
- The Krebs cycle, also known as the citric acid cycle or TCA cycle, takes place in the mitochondria of cells.

2. **Starting Molecules**:
- The cycle begins with the condensation of acetyl-CoA (acetyl coenzyme A) and oxaloacetic acid (a 4-carbon compound).

3. **Formation of Citric Acid**:
- When acetyl-CoA combines with oxaloacetic acid, it forms citric acid (a 6-carbon compound). This is the first product of the Krebs cycle.

4. **ATP Production**:
- Throughout the Krebs cycle, a total of 12 ATP molecules can be generated from one molecule of glucose, although the exact number can vary based on the specific conditions and the efficiency of the electron transport chain.

5. **Identifying the Wrong Statement**:
- The question asks for the wrong statement about the Krebs cycle. The incorrect statement is: "The cycle starts with the condensation of acetyl-CoA with pyruvic acid to yield citric acid."
- This statement is incorrect because the cycle actually starts with the condensation of acetyl-CoA with oxaloacetic acid, not pyruvic acid.

### Conclusion:
- The wrong statement regarding the Krebs cycle is that it starts with the condensation of acetyl-CoA with pyruvic acid to yield citric acid. The correct starting point is the combination of acetyl-CoA with oxaloacetic acid.

### Answer:
The wrong statement is: "The cycle starts with condensation of acetyl-CoA with pyruvic acid to yield citric acid."

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