What are the conditions responsible for more binding of `CO_(2)` with Hb in tissues ?

Explanation

To understand the conditions responsible for more binding of carbon dioxide (CO₂) with hemoglobin (Hb) in tissues, we can break it down into several key factors:

### Step-by-Step Solution:

1. **High Partial Pressure of CO₂**:
- In tissues, the metabolic activity produces CO₂ as a by-product. This leads to an increase in the partial pressure of CO₂ in the tissues. The higher the concentration of CO₂, the more likely it is to bind with hemoglobin.

2. **Low Partial Pressure of O₂**:
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