Transgenics have provided many pharamaceuticals in their milk, for treatment of diseases. Which one of the following has not been a successful story?

Options

A. Phenylketonuria
B. SCID
C. Emphysema (hereditary)
D. CFTR

Answer

### Step-by-Step Solution:

1. **Understanding Transgenics**: Transgenic organisms are those that have had foreign genes inserted into their genome. This genetic manipulation allows them to produce specific proteins or pharmaceuticals that can be beneficial for treating diseases.

2. **Pharmaceuticals in Milk**: Certain transgenic animals, particularly cows, goats, and sheep, have been engineered to produce therapeutic proteins in their milk. This milk can then be processed to extract these proteins for pharmaceutical use.

3. **Identifying Successful Applications**: Some successful applications of transgenic technology in pharmaceuticals include treatments for genetic disorders and other diseases. For example, transgenic cows have been used to produce proteins for conditions like cystic fibrosis.

4. **Analyzing the Options**: The question asks which of the following has not been a successful story in the context of transgenic milk providing pharmaceuticals.

5. **Phenylketonuria (PKU)**: This is a genetic disorder where individuals cannot metabolize phenylalanine, an amino acid found in many proteins, including those in milk. While there are efforts to create phenylalanine-free milk, it has not been a successful application of transgenic technology.

6. **Conclusion**: Among the options provided, phenylketonuria is the one that has not been successfully treated with pharmaceuticals derived from transgenic milk.

### Final Answer:
The successful story that has not been achieved is related to **Phenylketonuria (PKU)**.

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