The cells of connective tissue which produce histamine are

Options

A. Fibroblasts
B. Macrophages
C. Mast cells
D. Plasma cells

Answer

### Step-by-Step Text Solution:

1. **Understanding the Question**: The question asks which cells in connective tissue are responsible for producing histamine.

2. **Identifying Histamine**: Histamine is a chemical compound that plays a significant role in the immune response, particularly during allergic reactions.

3. **Recognizing the Source of Histamine**: Histamine is produced by specific cells in the body known as mast cells. These cells are part of the connective tissue and are crucial for the body's response to allergens.

4. **Role of Mast Cells**: When allergens (substances that can cause allergies) enter the body, they trigger an exaggerated immune response. This response stimulates mast cells to release histamine.

5. **Symptoms of Histamine Release**: The release of histamine leads to various allergy symptoms such as difficulty in breathing, redness, itching, watery eyes, and a runny nose.

6. **Conclusion**: Based on the information, the correct answer to the question is that mast cells are the cells of connective tissue that produce histamine.

### Final Answer:
The cells of connective tissue which produce histamine are **mast cells**.

---