Glucose does not react with

Options

A. `NH_(2)OH`
B. `C_(6)H_(5)NHNH_(2)`
C. `NaHSO_(3)`
D. HCN

Answer

To determine which compound glucose does not react with, we will analyze each of the given options one by one.

### Step-by-Step Solution:

1. **Identify the Structure of Glucose**:
- Glucose is an aldohexose, which means it contains six carbon atoms and has an aldehyde functional group (-CHO) at one end. Its molecular formula is C6H12O6.

2. **Analyze Reaction with Hydroxylamine (NH2OH)**:
- Hydroxylamine reacts with glucose to form an oxime. This is a characteristic reaction for compounds containing a carbonyl group (aldehyde or ketone).
- **Reaction**: Glucose + NH2OH → Glucosamine (oxime) + H2O.

3. **Analyze Reaction with Phenylhydrazine (C6H5NHNH2)**:
- Phenylhydrazine reacts with glucose to form phenylhydrazone and eventually osazone when three molecules are used.
- **Reaction**: Glucose + C6H5NHNH2 → Glucosazone + NH3 + H2O.

4. **Analyze Reaction with Sodium Bisulfite (NaHSO3)**:
- Sodium bisulfite typically reacts with free aldehyde groups to form bisulfite addition products. However, in glucose, the aldehyde group is involved in a hemiacetal formation, which means it is not free.
- **Conclusion**: Glucose does not react with NaHSO3.

5. **Analyze Reaction with Hydrogen Cyanide (HCN)**:
- HCN reacts with glucose to form cyanohydrin, confirming the presence of the carbonyl group.
- **Reaction**: Glucose + HCN → Glucose cyanohydrin.

6. **Analyze Reaction with Ammonia (NH3)**:
- Ammonia can also react with glucose, leading to the formation of an amine derivative.
- **Reaction**: Glucose + NH3 → Amine derivative.

### Final Conclusion:
- The only compound from the options that glucose does not react with is **Sodium Bisulfite (NaHSO3)**.

### Answer:
Glucose does not react with **NaHSO3 (Sodium Bisulfite)**.