In which of the following modes of inhibition, there is no direct interaction between inhibitors and active site of enzyme?

Options

A. Competitive inhibition predicted
B. Feedbock inhibition have
C. Non-competitive inhibition
D. Both (2)&(3)

Answer

To solve the question regarding the modes of inhibition where there is no direct interaction between inhibitors and the active site of the enzyme, we can analyze the different types of inhibition mentioned:

1. **Competitive Inhibition**: In this type of inhibition, the inhibitor competes with the substrate for the active site of the enzyme. Therefore, there is a direct interaction between the inhibitor and the active site.

2. **Non-Competitive Inhibition**: Here, the inhibitor binds to a site other than the active site. This binding changes the shape of the enzyme, preventing the substrate from binding effectively. Since the inhibitor does not bind to the active site, there is no direct interaction between the inhibitor and the active site.

3. **Feedback Inhibition**: In feedback inhibition, the end product of a metabolic pathway inhibits an earlier step in the pathway. The end product binds to an enzyme at a site other than the active site, thus preventing the enzyme from catalyzing the reaction. Similar to non-competitive inhibition, there is no direct interaction between the inhibitor (the end product) and the active site.

4. **Predictive Inhibition**: This term does not refer to a standard mode of enzyme inhibition recognized in biochemistry, so we can disregard it.

Given this analysis, we can conclude that both non-competitive inhibition and feedback inhibition do not involve direct interaction between the inhibitor and the active site of the enzyme.

**Final Answer**: The modes of inhibition where there is no direct interaction between inhibitors and the active site of the enzyme are **non-competitive inhibition and feedback inhibition**. Therefore, the answer is **both 2 and 3**.