Noble prize of 1978 for restriction endonuclease technology was given to :

Options

A. Temin and Baltimore
B. Milstein and Kohler
C. Arber, Nathans and Smith
D. Holley, Khorana and Nirenberg

Answer

To answer the question regarding who received the Nobel Prize in 1978 for restriction endonuclease technology, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Question**: The question asks about the recipients of the Nobel Prize in 1978 specifically related to restriction endonuclease technology.

2. **Identify the Relevant Nobel Prize Category**: The Nobel Prize in 1978 for this discovery was awarded in the field of Physiology or Medicine.

3. **Recall the Key Contributors**: The Nobel Prize was awarded to three scientists for their work related to restriction enzymes.

4. **List the Recipients**: The recipients of the Nobel Prize in 1978 were:
- Werner Arber
- Daniel Nathans
- Hamilton O. Smith

5. **Conclude the Answer**: Therefore, the correct answer to the question is that the Nobel Prize of 1978 for restriction endonuclease technology was awarded to Werner Arber, Daniel Nathans, and Hamilton O. Smith.

### Final Answer:
The Nobel Prize of 1978 for restriction endonuclease technology was given to **Werner Arber, Daniel Nathans, and Hamilton O. Smith**.