Which statement concerning ATP synthesis is true ?

Options

A. ATP can be synthesised through substrate level phosphorylation, photophosphorylation and oxidative phosphorylation
B. The proton-motive force is the establishment of proton gradients and electrochemical potentials across the inner membrane
C. Proton-motice force is essential for break flow of `H^(+)` from outer chamber of matrix of miotchondria through proton channel `(F_(0))` of `F_(0)-F_(1)` partticle to produce ATP
D. All

Answer

To determine which statement concerning ATP synthesis is true, we will analyze each option provided in the question.

### Step-by-Step Solution:

1. **Understanding ATP Synthesis**:
- ATP (adenosine triphosphate) is synthesized through various processes in cells, primarily during cellular respiration and photosynthesis.

2. **Evaluating Option 1**:
- This option states that ATP can be synthesized through substrate-level phosphorylation, photophosphorylation, and oxidative phosphorylation.
- **Substrate-level phosphorylation** occurs during glycolysis and the Krebs cycle.
- **Photophosphorylation** occurs during photosynthesis in the chloroplasts.
- **Oxidative phosphorylation** occurs in the mitochondria during the electron transport chain.
- This statement is true.

3. **Evaluating Option 2**:
- This option claims that the proton-motive force is the establishment of a proton gradient and electrochemical potential across the inner membrane.
- The proton-motive force is indeed created by the movement of protons (H⁺ ions) across a membrane, which creates both a concentration gradient and an electrical gradient.
- This statement is true.

4. **Evaluating Option 3**:
- This option states that the proton-motive force is essential for the flow of H⁺ ions from the outer chamber of the mitochondria to the matrix through the F0F1 ATP synthase complex.
- The flow of protons through ATP synthase (F0F1 complex) drives the synthesis of ATP from ADP and inorganic phosphate.
- This statement is true.

5. **Evaluating Option 4**:
- This option claims that all previous statements are correct.
- Since we have established that Options 1, 2, and 3 are true, this option is also true.

6. **Conclusion**:
- Since all statements regarding ATP synthesis are correct, the correct answer is **Option 4**: All.

### Final Answer:
The correct statement concerning ATP synthesis is **Option 4: All**.