I. ER divide the intracellular space into two distinct compartments.
II. SER is a major site for the synthesis of lipids.
III. ER is also called the control center of the cell.
IV. The ER modified chemicals that are toxin to the cell.
V. The ER with ribosomes in their surface is called RER.
Which of the following statements is /are true about the ER ?

Options

A. None
B. All except III , IV
C. All except III
D. All

Answer

To determine which statements about the endoplasmic reticulum (ER) are true, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Statement I: "ER divides the intracellular space into two distinct compartments."**
- The endoplasmic reticulum does indeed create two compartments within the cell: the rough endoplasmic reticulum (RER) and the smooth endoplasmic reticulum (SER). Therefore, this statement is **true**.

2. **Statement II: "SER is a major site for the synthesis of lipids."**
- The smooth endoplasmic reticulum is primarily involved in lipid synthesis, including phospholipids and steroids. Thus, this statement is also **true**.

3. **Statement III: "ER is also called the control center of the cell."**
- This statement is **false**. The control center of the cell is the nucleus, which regulates cellular activities and gene expression. The ER does not serve this function.

4. **Statement IV: "The ER modifies chemicals that are toxins to the cell."**
- The smooth endoplasmic reticulum plays a crucial role in detoxifying harmful substances, particularly in the liver. Therefore, this statement is **true**.

5. **Statement V: "The ER with ribosomes on its surface is called RER."**
- The rough endoplasmic reticulum is characterized by the presence of ribosomes on its surface, which gives it a "rough" appearance. Hence, this statement is **true**.

### Conclusion:
The true statements about the endoplasmic reticulum (ER) are I, II, IV, and V. The only false statement is III. Therefore, the answer is that all statements are correct except for statement III.