DNA is a polymer of nucleotides which ar...

DNA is a polymer of nucleotides which are linked to each other by `3'-5'` phosphodiester bond . To prevent polymerisation of nucleotides, which of the following modifications would you choose ?

Replace purine with pyrimidines

Remove/Replace 3' OH group in deoxy ribose

Remove/Replace 2' OH group with some other group in deoxy ribose

Both ((b) and (c)

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