Addisons disease is due to under-secretion of

Options

A. Adrenaline
B. Corticoids/Adrenals
C. ACTH
D. Insulin.

Answer

**Step-by-Step Solution:**

1. **Understanding Addison's Disease**: Addison's disease is a disorder that occurs when the adrenal glands do not produce enough hormones. It is primarily characterized by the under-secretion of certain hormones, specifically cortisol and aldosterone.

2. **Identifying the Hormones**: The adrenal glands produce several hormones, including adrenaline, cortisol, and aldosterone. In the context of Addison's disease, we need to focus on the hormones that are under-secreted.

3. **Analyzing the Options**:
- **Adrenaline**: This hormone is produced by the adrenal medulla and is primarily involved in the body's fight-or-flight response. It does not play a direct role in Addison's disease.
- **Corticoids (Cortisol and Aldosterone)**: These hormones are produced by the adrenal cortex. Cortisol helps regulate metabolism and stress response, while aldosterone regulates sodium and water balance. Their under-secretion is directly related to Addison's disease.
- **ACTH (Adrenocorticotropic Hormone)**: This hormone is produced by the pituitary gland and stimulates the adrenal cortex to produce cortisol. It is not the hormone that is under-secreted in Addison's disease.
- **Insulin**: This hormone is produced by the pancreas and regulates blood glucose levels. It is not related to Addison's disease.

4. **Conclusion**: The correct answer is that Addison's disease is due to the under-secretion of corticoids (cortisol and aldosterone).

**Final Answer**: Addison's disease is due to the under-secretion of corticoids (cortisol and aldosterone).

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