Disease caused by hyper-or-hypo secretion of thyroxme is 

Options

A. Cretinism
B. Acromegaly
C. Goitre
D. both a and c

Answer

**Step-by-Step Solution:**

1. **Understanding Thyroxine:**
- Thyroxine is a hormone produced by the thyroid gland that plays a crucial role in regulating metabolism, growth, and development in the body.

2. **Identifying Hypersecretion and Hyposecretion:**
- Hypersecretion of thyroxine refers to an excessive production of this hormone, while hyposecretion refers to insufficient production.

3. **Diseases Associated with Thyroxine Levels:**
- **Cretinism:** This condition is associated with hyposecretion of thyroxine during infancy or early childhood, leading to severe mental and physical developmental delays.
- **Goiter:** This condition occurs due to hyposecretion of thyroxine, often resulting from iodine deficiency. The thyroid gland enlarges to compensate for the low levels of thyroxine, leading to a visible swelling in the neck.

4. **Acromegaly:**
- This is not directly related to thyroxine but is a condition caused by hypersecretion of growth hormone, leading to abnormal growth of bones and tissues in adults.

5. **Conclusion:**
- The diseases caused by hypersecretion or hyposecretion of thyroxine are:
- Cretinism (hyposecretion)
- Goiter (hyposecretion)
- Therefore, the correct answer is both A (Cretinism) and C (Goiter).

**Final Answer:** The diseases caused by hyper-or-hyposecretion of thyroxine are Cretinism and Goiter.

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