Nonsecretion of uric acid in human beings produces

Options

A. Uraemia
B. Gout
C. Calculi
D. Both B and C.

Answer

To solve the question regarding the consequences of non-secretion of uric acid in human beings, let's break it down step by step.

### Step-by-Step Solution:

1. **Understanding Uric Acid**:
- Uric acid is a waste product formed from the breakdown of purines, which are found in certain foods and drinks. It is normally excreted by the kidneys.

2. **Effects of Non-Secretion**:
- When uric acid is not properly secreted or eliminated from the body, it can lead to various health issues.

3. **Gout**:
- One of the primary conditions associated with the accumulation of uric acid is gout. This occurs when uric acid crystals deposit in the joints, leading to inflammation and severe pain, particularly in the knees and other joints.

4. **Calculi (Kidney Stones)**:
- Additionally, excess uric acid can lead to the formation of kidney stones (calculi). These stones are formed when uric acid crystallizes in the kidneys, causing blockages and pain.

5. **Uremia**:
- Uremia is a condition that occurs when the kidneys are unable to filter waste products from the blood effectively. While it can be a consequence of kidney failure, it is not directly caused by the non-secretion of uric acid alone.

6. **Conclusion**:
- Since non-secretion of uric acid can lead to both gout and calculi, the correct answer to the question is that it produces both gout and calculi.

### Final Answer:
- The correct option is **4: Both B and C (gout and calculi)**.