The technique of production of monoclonal antibodies was developed by

Options

A. Watson and Crick
B. Milstein and Kohler
C. Bentham and Hooker
D. Miescher

Answer

**Step-by-Step Text Solution:**

1. **Identify the Technique**: The technique for the production of monoclonal antibodies is known as hybridoma technology.

2. **Historical Context**: This technique was developed in 1975 by two scientists, Georges Köhler and César Milstein.

3. **Understanding Hybridoma Technology**: Hybridoma technology involves the fusion of an antibody-producing B cell with a myeloma (cancer) cell. This fusion creates a hybrid cell, known as a hybridoma, which can produce a specific type of antibody indefinitely.

4. **Significance of Monoclonal Antibodies**: Monoclonal antibodies are identical antibodies produced by a single clone of B cells. They are used in various applications, including diagnostics, therapeutics, and research.

5. **Recognition of Contribution**: For their pioneering work in developing monoclonal antibodies, Köhler and Milstein were awarded the Nobel Prize in Physiology or Medicine in 1984.

**Final Answer**: The technique of production of monoclonal antibodies was developed by Georges Köhler and César Milstein.

---