Hybridoma is connected with:

Options

A. (a) Growth of cancer
B. (b) Monoclonal antibody formation
C. (c) Antibody-antigen interaction
D. (d) Activity of NK cells

Answer

**Step-by-Step Solution:**

1. **Understanding Hybridoma Technology**:
- Hybridoma technology involves the fusion of B cells (which produce antibodies) with myeloma cells (cancerous cells that can divide indefinitely). This fusion creates hybridoma cells that possess the properties of both parent cells.

2. **Role of Mice**:
- In this process, mice are immunized with specific antigens. This immunization prompts the mouse's immune system to produce B cells that create antibodies against those antigens.

3. **Isolation and Fusion**:
- After immunization, B cells are isolated from the mouse. These B cells are then fused with myeloma cells to create hybridoma cells.

4. **Selection of Hybridoma Cells**:
- The hybridoma cells are selected using a special medium that allows only the hybridoma cells to survive, while the individual B cells and myeloma cells are eliminated.

5. **Production of Monoclonal Antibodies**:
- The selected hybridoma cells are then cultured in bioreactors, where they proliferate and produce monoclonal antibodies. These antibodies are specific to the antigen used during the immunization of the mouse.

6. **Therapeutic Applications**:
- Monoclonal antibodies produced through hybridoma technology have significant therapeutic applications, including treatment for diseases such as cancer, asthma, and arthritis.

7. **Conclusion**:
- Therefore, hybridoma technology is primarily connected with the production of monoclonal antibodies.

**Final Answer**: Hybridoma is connected with the production of monoclonal antibodies.

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