Cystic fibrosis can be treated by -in gene therapy

Options

A. TGP-B
B. TPA
C. Dnase
D. BGH

Answer

### Step-by-Step Solution:

1. **Understanding Cystic Fibrosis**:
- Cystic fibrosis is an autosomal recessive genetic disorder. This means that it is caused by mutations in genes inherited from both parents. The specific gene involved is located on chromosome 7.

2. **Symptoms and Effects**:
- The disorder primarily affects the lungs and digestive system. It leads to the production of thick and sticky mucus, which can obstruct airways and lead to frequent lung infections, such as pneumonia.

3. **Gene Involvement**:
- The defective gene responsible for cystic fibrosis is called the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator). This gene is crucial for the regulation of salt and water transport in epithelial cells.

4. **Mechanism of Gene Therapy**:
- Gene therapy aims to correct or replace the defective CFTR gene. However, in the context of treating symptoms, a different approach can be taken using enzymes.

5. **Use of DNase in Treatment**:
- One of the treatments for cystic fibrosis involves using an enzyme called DNase (Deoxyribonuclease). This enzyme helps to break down the thick mucus in the lungs, reducing its viscosity and making it easier for patients to expel the mucus.

6. **Outcome of Treatment**:
- By using DNase, the viscosity of sputum is decreased, which helps in clearing the airways and reducing the frequency of lung infections. This can significantly improve the quality of life for individuals suffering from cystic fibrosis.