Colchicine arrest mitosis at

Options

A. prophase
B. metaphase
C. anaphase
D. interphase

Explanation

**Step-by-Step Solution:**

1. **Understanding Colchicine**: Colchicine is a chemical compound derived from the plant Colchicum autumnale. It is commonly used in laboratories to study cell division.

2. **Function of Colchicine**: The primary function of colchicine is to inhibit the formation of spindle fibers during cell division. Spindle fibers are crucial for the proper segregation of chromosomes during mitosis.

3. **Timing of Spindle Fiber Formation**: Spindle fibers begin to form during the metaphase stage of mitosis. This is when chromosomes align at the equatorial plate of the cell.

4. **Effect of Colchicine on Mitosis**: When colchicine is present, it prevents the formation of spindle fibers. As a result, the cell cannot progress beyond the metaphase stage.

5. **Arresting of Cells**: Due to the absence of spindle fibers, the chromosomes remain aligned at the equatorial plate, effectively arresting the cell in the metaphase stage of mitosis.

6. **Conclusion**: Therefore, colchicine arrests mitosis at the metaphase stage.

**Final Answer**: Colchicine arrests mitosis at metaphase.

---