Explain the production of human growth Hormone in E.coli.

Explanation

Production of human growth hormone by E. coli. The Human growth hormone is produced commercially by transgenic Escherichia coli. The pituitary gland of humans produces growth hormones that regulate the growth and development. However, in children stunted growth occurs due to deficiency of the hormone called as pituitary dwarfism. For this, the hGH is now available as recombinant protein. The hGH-coding DNA sequence is linked with the bacterial signal sequence of E. coli. The hGH is secreted into the periplasmic space of bacterial cell by the signal peptides where from the protein is purified.