Trisomic autosomal congenital disease is

Options

A. Criminal syndrome
B. Down's syndrome
C. Klinefelter's syndrome
D. Turner's syndrome

Answer

**Step-by-Step Solution:**

1. **Understanding Trisomy**: Trisomy is a genetic condition where an individual has three copies of a particular chromosome instead of the usual two. This can lead to various congenital diseases.

2. **Identifying Autosomal Chromosomes**: Autosomes are chromosomes that are not involved in determining the sex of an individual. Humans have 22 pairs of autosomes and one pair of sex chromosomes (XX for females and XY for males).

3. **Recognizing Congenital Diseases**: Congenital diseases are conditions that are present at birth, which can be caused by genetic abnormalities, environmental factors, or a combination of both.

4. **Analyzing the Options**:
- **Klinefelter Syndrome**: This is caused by an extra X chromosome in males (XXY), making it a sex-linked condition.
- **Turner Syndrome**: This condition occurs when there is a missing X chromosome in females (X0), also a sex-linked condition.
- **Criminal Syndrome (Jacob Syndrome)**: This is due to an extra Y chromosome in males (XYY), which is again a sex-linked condition.
- **Down Syndrome**: This condition is also known as Trisomy 21, where there is an extra copy of chromosome 21, making it an autosomal congenital disease.

5. **Conclusion**: Based on the analysis, Down Syndrome is the only condition listed that is classified as a trisomic autosomal congenital disease.

**Final Answer**: Down Syndrome

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