Nuclear membrane and Nucleolus will disappear at the end of :

Options

A. Leptotene
B. Zygotene
C. Diplotene
D. Diakinesis

Answer

To determine when the nuclear membrane and nucleolus disappear during meiosis, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Context of Meiosis**: Meiosis is a type of cell division that reduces the chromosome number by half and involves two successive divisions, meiosis I and meiosis II. It consists of several phases.

2. **Identify the Phases of Meiosis**: The prophase of meiosis is divided into several sub-phases: leptotene, zygotene, pachytene, diplotene, and finally, diakinesis.

3. **Focus on Diakinesis**: Diakinesis is the last stage of prophase I in meiosis. During this phase, significant changes occur in the cell, particularly concerning the nuclear components.

4. **Observe Changes in Nuclear Components**: During diakinesis, the nuclear membrane and nucleolus undergo significant changes. Specifically, they begin to disappear, which is crucial for the progression of meiosis.

5. **Confirm the Characteristics of Diakinesis**: In addition to the disappearance of the nuclear membrane and nucleolus, diakinesis is characterized by the shortening and thickening of chromosomes and the formation of spindle fibers.

6. **Conclude the Answer**: Based on the information gathered, we conclude that the nuclear membrane and nucleolus disappear at the end of the diakinesis phase of meiosis.

### Final Answer:
The nuclear membrane and nucleolus will disappear at the end of **diakinesis** (Option 4).